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Article

Domains involved in calcineurin phosphatase inhibition and nuclear localisation in the African swine fever virus A238L protein.

Virology - 10 May 2008

Abrams Charles C, Chapman Dave A G, Silk Rhiannon, Liverani Elisabetta, Dixon Linda K

Abstract excerpt

The African swine fever virus A238L protein inhibits calcineurin phosphatase activity and activation of NF-kappaB and p300 co-activator. An 82 amino acid domain containing residues 157 to 238 at the C-terminus of A238L was expressed in E. coli and purified. This purified A238L fragment acted as a potent inhibitor of calcineurin phosphatase in vitro with an IC50 of approximately 70 nM. Two putative nuclear...

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Identifiers

PMID: 18261759
DOI: 10.1016/j.virol.2008.01.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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