Article
Haptoglobin polymorphism: a novel genetic risk factor for celiac disease development and its clinical manifestations.
Clinical chemistry - 1 Apr 2008
Papp Maria, Foldi Ildiko, Nemes Eva, Udvardy Miklos, Harsfalvi Jolan, Altorjay Istvan, Mate Istvan, Dinya Tamas, Varvolgyi Csaba, Barta Zsolt, Veres Gabor, Lakatos Peter Laszlo, Tumpek Judit, Toth Laszlo, Szathmari Erzsebet, Kapitany Aniko, Gyetvai Agnes, Korponay-Szabo Ilma R
Abstract excerpt
BACKGROUND: Haptoglobin (Hp) alpha-chain alleles 1 and 2 account for 3 phenotypes that may influence the course of inflammatory diseases via biologically important differences in their antioxidant, scavenging, and immunomodulatory properties. Hp1-1 genotype results in the production of small dimeric, Hp2-1 linear, and Hp2-2 cyclic polymeric haptoglobin molecules. We investigated the haptoglobin polymorphism in...
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