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Article

Formation of engineered intersubunit disulfide bond in cytochrome bc1 complex disrupts electron transfer activity in the complex.

Biochimica et biophysica acta - 1 Mar 2008

Ma He-Wen, Yang Shaoqing, Yu Linda, Yu Chang-An

Abstract excerpt

Protein domain movement of the Rieske iron-sulfur protein has been speculated to play an essential role in the bifurcated oxidation of ubiquinol catalyzed by the cytochrome bc1 complex. To better understand the electron transfer mechanism of the bifurcated ubiquinol oxidation at Qp site, we fixed the head domain of ISP at the cyt c1 position by creating an intersubunit disulfide bond between two genetically...

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Identifiers

PMID: 18258178
DOI: 10.1016/j.bbabio.2008.01.005
PMCID: PMC2605939

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