Article
Vitamin D receptor polymorphisms and renal cancer risk in Central and Eastern Europe.
Journal of toxicology and environmental health. Part A - 1 Jan 2008
Karami S, Brennan P, Hung R J, Boffetta P, Toro J, Wilson R T, Zaridze D, Navratilova M, Chatterjee N, Mates D, Janout V, Kollarova H, Bencko V, Szeszenia-Dabrowska N, Holcatova I, Moukeria A, Welch R, Chanock S, Rothman N, Chow W-H, Moore L E
Abstract excerpt
Previous studies investigated the role of vitamin D intake and cancer risk. The kidney is a major organ for vitamin D metabolism, activity, and calcium homeostasis; therefore, it was hypothesized that dietary vitamin D intake and polymorphisms in the vitamin D receptor (VDR) gene may modify renal cell carcinoma (RCC) risk. Three common VDR gene polymorphisms (BsmI, FokI, TaqI) were evaluated among 925 RCC cases...
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