Article
On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test.
Genetic epidemiology - 1 Apr 2008
Ionita-Laza Iuliana, Perry George H, Raby Benjamin A, Klanderman Barbara, Lee Charles, Laird Nan M, Weiss Scott T, Lange Christoph
Abstract excerpt
Though there is an increasing support for an important contribution of copy number variation (CNV) to the genetic architecture of complex disease, few methods have been developed for the analysis of such variation in the context of genetic association studies. In this paper, we propose a generalization of family-based association tests (FBATs) to allow for the analysis of CNVs at a genome-wide level. We translate...
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