Article
Relationship between mRNA secondary structure and sequence variability in Chloroplast genes: possible life history implications.
BMC genomics - 28 Jan 2008
Krishnan Neeraja M, Seligmann Hervé, Rao Basuthkar J
Abstract excerpt
BACKGROUND: Synonymous sites are freer to vary because of redundancy in genetic code. Messenger RNA secondary structure restricts this freedom, as revealed by previous findings in mitochondrial genes that mutations at third codon position nucleotides in helices are more selected against than those in loops. This motivated us to explore the constraints imposed by mRNA secondary structure on evolutionary...
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