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Article

PTPN22 is genetically associated with risk of generalized vitiligo, but CTLA4 is not.

The Journal of investigative dermatology - 1 Jul 2008

LaBerge Greggory S, Bennett Dorothy C, Fain Pamela R, Spritz Richard A

Abstract excerpt

Generalized vitiligo is an acquired, multifactorial, polygenic disease in which depigmented spots of skin, overlying hair, and mucus membranes result from autoimmune-mediated loss of melanocytes from affected areas. We examined single-nucleotide polymorphisms (SNPs) in the PTPN22 and CTLA4 genes in 126 Caucasian families with multiple cases of generalized vitiligo and associated autoimmune diseases, using a...

Read the complete abstract on PubMed

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Share to Antigens, CD
Share to Autoimmunity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CTLA-4 Antigen

Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to Vitiligo

Source

Identifiers

PMID: 18200060
DOI: 10.1038/sj.jid.5701233

Genes

PTPN22
CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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