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Article

PTPN22 is genetically associated with risk of generalized vitiligo, but CTLA4 is not.

The Journal of investigative dermatology - 1 Jul 2008

LaBerge Greggory S, Bennett Dorothy C, Fain Pamela R, Spritz Richard A

Abstract excerpt

Generalized vitiligo is an acquired, multifactorial, polygenic disease in which depigmented spots of skin, overlying hair, and mucus membranes result from autoimmune-mediated loss of melanocytes from affected areas. We examined single-nucleotide polymorphisms (SNPs) in the PTPN22 and CTLA4 genes...

Read the complete abstract on PubMed

Topics

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Share to Antigens, CD
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CTLA-4 Antigen

Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

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Source

Identifiers

PMID: 18200060
DOI: 10.1038/sj.jid.5701233

Genes

PTPN22
CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18200060-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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