Characterization of the Trichomonas vaginalis surface-associated AP65 and binding domain interacting with trichomonads and host cells

Abstract excerpt

BACKGROUND: AP65 is a prominent adhesin of Trichomonas vaginalis that mediates binding of parasites to host vaginal epithelial cells (VECs). AP65 with no secretion signal sequence, membrane targeting peptide, and anchoring motif was recently found to be secreted. RESULTS: We first wanted to demonstrate surface association of AP65 to the parasite followed by the identification of the binding epitope interacting...

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