Article
A Temperature-sensitive mutation in the Arabidopsis thaliana phosphomannomutase gene disrupts protein glycosylation and triggers cell death.
The Journal of biological chemistry - 29 Feb 2008
Hoeberichts Frank A, Vaeck Elke, Kiddle Guy, Coppens Emmy, van de Cotte Brigitte, Adamantidis Antoine, Ormenese Sandra, Foyer Christine H, Zabeau Marc, Inzé Dirk, Périlleux Claire, Van Breusegem Frank, Vuylsteke Marnik
Abstract excerpt
Eukaryotic phosphomannomutases (PMMs) catalyze the interconversion of mannose 6-phosphate to mannose 1-phosphate and are essential to the biosynthesis of GDP-mannose. As such, plant PMMs are involved in ascorbic acid (AsA) biosynthesis and N-glycosylation. We report on the conditional phenotype of the temperature-sensitive Arabidopsis thaliana pmm-12 mutant. Mutant seedlings were phenotypically similar to wild...
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