Article
Increased forensic efficiency of DNA fingerprints through simultaneous resolution of length and nucleotide variability by high-performance mass spectrometry.
Human mutation - 1 Mar 2008
Oberacher Herbert, Pitterl Florian, Huber Gabriela, Niederstätter Harald, Steinlechner Martin, Parson Walther
Abstract excerpt
Short tandem repeat (STR) typing is the most powerful method for determining the origin of a sample for a number of molecular disciplines such as medical genetics, population genetics, tumor analysis, transplantation medicine, or forensic crime scene analysis. STR alleles are routinely differentiated based upon their fragment size by electrophoresis under denaturing conditions, which does not take nucleotide...
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