Article
BDNF A196G and C270T gene polymorphisms and susceptibility to multiple sclerosis in the Polish population. Gender differences.
Journal of neuroimmunology - 1 Jan 2008
Mirowska-Guzel Dagmara, Mach Anna, Gromadzka Grazyna, Czlonkowski Andrzej, Czlonkowska Anna
Abstract excerpt
Two single nucleotide polymorphisms of the human BDNF gene, G196A and C270T, and their impact on the susceptibility to MS and disease progression in the Polish population were investigated. Increased risk of the disease was found for 196G/G carriers (OR -- 1.63, p=0.01) (only females) and 270C/T carriers (OR -- 7.76, p<0.001) (both males and females). The first signs of the disease appeared earlier in 196G/G than...
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