Article
Profiling of copy number variations (CNVs) in healthy individuals from three ethnic groups using a human genome 32 K BAC-clone-based array.
Human mutation - 1 Mar 2008
Díaz de Ståhl Teresita, Sandgren Johanna, Piotrowski Arkadiusz, Nord Helena, Andersson Robin, Menzel Uwe, Bogdan Adam, Thuresson Ann-Charlotte, Poplawski Andrzej, von Tell Desiree, Hansson Caisa M, Elshafie Amir I, Elghazali Gehad, Imreh Stephan, Nordenskjöld Magnus, Upadhyaya Meena, Komorowski Jan, Bruder Carl E G, Dumanski Jan P
Abstract excerpt
To further explore the extent of structural large-scale variation in the human genome, we assessed copy number variations (CNVs) in a series of 71 healthy subjects from three ethnic groups. CNVs were analyzed using comparative genomic hybridization (CGH) to a BAC array covering the human genome, using DNA extracted from peripheral blood, thus avoiding any culture-induced rearrangements. By applying a newly...
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