Article
Association of transforming growth factor-beta1 gene polymorphism in the development of Epstein-Barr virus-related hematologic diseases.
Haematologica - 1 Nov 2007
Hatta Kanako, Morimoto Akira, Ishii Eiichi, Kimura Hiroshi, Ueda Ikuyo, Hibi Shigeyoshi, Todo Shinjiro, Sugimoto Tohru, Imashuku Shinsaku
Abstract excerpt
BACKGROUND AND OBJECTIVES: Epstein-Barr virus (EBV) is etiologically associated with various hematologic disorders, including primary acute infectious mononucleosis (IM), hemophagocytic lymphohistiocytosis (EBV-HLH), chronic active EBV infection (CAEBV) and malignant lymphomas. Although cytokines play a central role in EBV-related immune responses, the exact mechanisms causing different clinical responses remain...
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