Article
Genetic alteration in hereditary colorectal cancer.
Surgical oncology - 1 Dec 2007
Dionigi G, Bianchi V, Rovera F, Boni L, Annoni M, Castano P, Villa F, Dionigi R
Abstract excerpt
Colorectal cancer is a major cause of morbidity and mortality. Both genetic and environmental factors contribute to cancer aetiology. About 15-20% of all colorectal cancers are familial. Approximately 6% of colorectal cancers can be attributed to recognizable heritable germline mutations. The discovery of genes responsible for inherited forms of colorectal cancer have the potential to improve cancer risk...
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