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Article

Expression of a Cu,Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury.

BMC infectious diseases - 12 Nov 2007

Goos Miriam, Zech Wolf-Dieter, Jaiswal Manoj Kumar, Balakrishnan Saju, Ebert Sandra, Mitchell Timothy, Carrì Maria Teresa, Keller Bernhard U, Nau Roland

Abstract excerpt

BACKGROUND: Infections can aggravate the course of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Mutations in the anti-oxidant enzyme Cu,Zn superoxide dismutase (EC 1.15.1.1, SOD1) are associated with familial ALS. Streptococcus pneumoniae, the most frequent respiratory pathogen, causes damage by the action of the cholesterol-binding virulence factor pneumolysin and by stimulation of...

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Identifiers

PMID: 17997855
DOI: 10.1186/1471-2334-7-131
PMCID: PMC2211486

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression of a Cu,Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury.PMID 17997855Read ↗

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