Article
Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene.
Leukemia research - 1 Jun 2008
Nishioka Chie, Ikezoe Takayuki, Yang Jing, Takeshita Ayako, Taniguchi Ayuko, Komatsu Naoki, Togitani Kazuto, Koeffler H Phillip, Yokoyama Akihito
Abstract excerpt
The FMS-like tyrosine kinase 3 (FLT3) is a cell surface receptor tyrosine kinase. Activating mutations of this gene occur in nearly 30% of acute myelogenous leukemia (AML) patients. These mutations, in part, result in activation of mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathways. In this study, we found that AZD6244 (ARRY-142886), a novel inhibitor of MEK1/2...
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