Article
Variable outcome of growth hormone administration in respiratory chain deficiency.
Molecular genetics and metabolism - 1 Feb 2008
Romano S, Samara D, Crosnier H, Valayannopoulos V, Polak M, Chrétien D, Rötig A, Munnich A, Brauner R, de Lonlay P
Abstract excerpt
Genetic defects of oxidative phosphorylation (OXPHOS) are known to account for a variety of neuromuscular and non-neuromuscular symptoms in childhood, including growth hormone (GH) deficiency. However GH administration for GH deficiency is controversial in OXPHOS deficiencies as GH is a mitosis-stimulator which may increase energy demand for cell proliferation. Here, we report the observation of four unrelated...
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