Article
The contribution of GJB2 (Connexin 26) 35delG to age-related hearing impairment and noise-induced hearing loss.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology - 1 Oct 2007
Van Eyken Els, Van Laer Lut, Fransen Erik, Topsakal Vedat, Hendrickx Jan-Jaap, Demeester Kelly, Van de Heyning Paul, Mäki-Torkko Elina, Hannula Samuli, Sorri Martti, Jensen Mona, Parving Agnete, Bille Michael, Baur Manuela, Pfister Markus, Bonaconsa Amanda, Mazzoli Manuela, Orzan Eva, Espeso Angeles, Stephens Dafydd, Verbruggen Katia, Huyghe Joke, Dhooge Ingeborg, Huygen Patrick, Kremer Hannie, Cremers Cor, Kunst Sylvia, Manninen Mina, Pyykkö Ilmari, Rajkowska Elzbieta, Pawelczyk Malgorzata, Sliwinska-Kowalska Mariola, Steffens Michael, Wienker Thomas, Van Camp Guy
Abstract excerpt
HYPOTHESIS: The common GJB2 (Connexin 26) 35delG mutation might contribute to the development of age-related hearing impairment (ARHI) and noise-induced hearing loss (NIHL). BACKGROUND: GJB2, a gene encoding a gap junction protein expressed in the inner ear, has been suggested to be involved in the potassium recycling pathway in the cochlea. GJB2 mutations account for a large number of individuals with...
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