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Article

Superimposed segmental manifestation of polygenic skin disorders.

Journal of the American Academy of Dermatology - 1 Oct 2007

Happle Rudolf

Abstract excerpt

In common acquired skin disorders with a polygenic background such as psoriasis, a linear or otherwise segmental arrangement may sometimes be noted. The segmental involvement tends to be rather severe and may be associated with milder, nonsegmental lesions of the same disorder. Such cases may be best explained by an early postzygotic event in the form of loss of heterozygosity involving one of the genes that...

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PMID: 17870433
DOI: 10.1016/j.jaad.2007.06.039

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