Article
Candida albicans THI13 disruption affects production of monocytic cytokines.
Oral microbiology and immunology - 1 Oct 2007
Zhu Z Y, Cao Y Y, Wang Y, Quan H, Zhao J X, Jia X M, Cao Y B, Gao P H, Xu Z, Jiang Y Y
Abstract excerpt
INTRODUCTION: The Candida albicansTHI13 gene was identified by its homology to the Candida tropicalis CtNMT1 gene, which is involved in pyrimidine precursor biosynthesis. METHODS: Disruption of THI13 revealed that this gene played a minor role in thiamin biosynthesis in C. albicans. Purified human monocytes were incubated with C. albicans at the optimal Candida: monocyte ratio of 0.5 and cytokines in the...
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