Article
Phase 2B trial of aminopterin in multiagent therapy for children with newly diagnosed acute lymphoblastic leukemia.
Cancer chemotherapy and pharmacology - 1 Jun 2008
Cole Peter D, Drachtman Richard A, Masterson Margaret, Smith Angela K, Glod John, Zebala John A, Lisi Stacey, Drapala Drew-Anne, Kamen Barton A
Abstract excerpt
PURPOSE: Aminopterin offers advantages over the related antifolate, methotrexate, including greater potency, complete bioavailability, and more consistent accumulation and metabolism by patients' blasts. This current trial was done to document the toxicity of the aminopterin within a multiagent therapeutic regimen for children with newly diagnosed ALL. EXPERIMENTAL DESIGN: Patients at high risk of relapse were...
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