Presence of simian virus 40 DNA sequences in diffuse large B‐cell lymphomas in Tunisia correlates with aberrant promoter hypermethylation of multiple tumor suppressor genes

Abstract excerpt

The simian virus SV40 (SV40), a potent DNA oncogenic polyomavirus, has been detected in several human tumors including lymphomas, mainly in diffuse large B-cell type (DLBCL). However, a causative role for this virus has not been convincingly established. Hypermethylation in promoter regions is a frequent process of silencing tumor suppressor genes (TSGs) in cancers, which may be induced by oncogenic viruses. In...

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