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Article

Polycystic ovary syndrome is associated with genetic polymorphism in the insulin signaling gene IRS-1 but not ENPP1 in a Japanese population.

Life sciences - 16 Aug 2007

Baba Tsuyoshi, Endo Toshiaki, Sata Fumihiro, Honnma Hiroyuki, Kitajima Yoshimitsu, Hayashi Takuhiro, Manase Kengo, Kanaya Mika, Yamada Hideto, Minakami Hisanori, Kishi Reiko, Saito Tsuyoshi

Abstract excerpt

Recent studies indicate that insulin resistance resulting from altered post-receptor signaling is associated with polycystic ovary syndrome (PCOS). We hypothesized that insulin receptor substrate-1 (IRS-1) Gly972Arg polymorphism and/or ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) Lys121Gln polymorphism predisposes women to PCOS and that these polymorphisms also affect anthropometric variables,...

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Identifiers

PMID: 17719609
DOI: 10.1016/j.lfs.2007.07.023

Genes

ENPP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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