Article
Combination of Helicobacter pylori strain and tumor necrosis factor-alpha polymorphism of the host increases the risk of peptic ulcer disease in children.
Journal of pediatric gastroenterology and nutrition - 1 Aug 2007
Wilschanski Michael, Schlesinger Yechiel, Faber Joseph, Rudensky Berl, Ohnona Fred S, Freier Serem, Rahman Elena, Refael Shira, Halle David
Abstract excerpt
BACKGROUND: Helicobacter pylori infection is probably acquired in childhood and causes a vigorous immune response. It is unclear why only a subgroup of infected children develops peptic ulcer disease. We have previously reported that iceA1 strains tend to be associated with duodenal disease in children. However, the pathogenesis probably does not depend solely on the H pylori strain but also on the variability of...
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