Article
Mesophilic Aeromonas UDP-glucose pyrophosphorylase (GalU) mutants show two types of lipopolysaccharide structures and reduced virulence.
Microbiology (Reading, England) - 1 Aug 2007
Vilches Silvia, Canals Rocío, Wilhelms Markus, Saló Maria Teresa, Knirel Yuriy A, Vinogradov Evgeny, Merino Susana, Tomás Juan M
Abstract excerpt
A mutation in galU that causes the lack of O34-antigen lipopolysaccharide (LPS) in Aeromonas hydrophila strain AH-3 was identified. It was proved that A. hydrophila GalU is a UDP-glucose pyrophosphorylase responsible for synthesis of UDP-glucose from glucose 1-phosphate and UTP. The galU mutant from this strain showed two types of LPS structures, represented by two bands on LPS gels. The first one (slow-migrating...
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