Article
Recombinant human parainfluenza virus type 2 vaccine candidates containing a 3' genomic promoter mutation and L polymerase mutations are attenuated and protective in non-human primates.
Vaccine - 21 Aug 2007
Nolan Sheila M, Skiadopoulos Mario H, Bradley Konrad, Kim Olivia S, Bier Stacia, Amaro-Carambot Emerito, Surman Sonja R, Davis Stephanie, St Claire Marisa, Elkins Randy, Collins Peter L, Murphy Brian R, Schaap-Nutt Anne
Abstract excerpt
Previously, we identified several attenuating mutations in the L polymerase protein of human parainfluenza virus type 2 (HPIV2) and genetically stabilized those mutations using reverse genetics [Nolan SM, Surman S, Amaro-Carambot E, Collins PL, Murphy BR, Skiadopoulos MH. Live-attenuated intranas...
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