Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metabolic plasticity during mammalian development is directionally dependent on early nutritional status.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jul 2007

Gluckman Peter D, Lillycrop Karen A, Vickers Mark H, Pleasants Anthony B, Phillips Emma S, Beedle Alan S, Burdge Graham C, Hanson Mark A

Abstract excerpt

Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for most mammalian traits. The metabolic phenotype of adult rats, including the propensity to obesity, hyperinsulinemia, and hyperphagia, shows plasticity in response to prenatal nutrition and to neonatal administration of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Leptin

Share to Nutritional Status

Share to Pregnancy

Share to Rats, Wistar

Source

Open in PubMed Open full text

Identifiers

PMID: 17646663
DOI: 10.1073/pnas.0705667104
PMCID: PMC1937546

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabolic plasticity during mammalian development is directionally dependent on early nutritional status.PMID 17646663Read ↗

The biology of developmental plasticity and the Predictive Adaptive Response hypothesisSemantic proximity Read ↗

Developmental Programming of Energy Balance and Its Hypothalamic RegulationSemantic proximity Read ↗

Transcriptional profiling of rats subjected to gestational undernourishment: implications for the developmental variations in metabolic traits.Semantic proximity Read ↗

Phenotypic plasticity: molecular mechanisms and adaptive significance.Semantic proximity Read ↗

Mechanisms underlying phenotypic plasticity in response to environmental change.Semantic proximity Read ↗

Sucrose feeding during pregnancy and lactation elicits distinct metabolic response in offspring of an inbred genetic model of metabolic syndromeSemantic proximity Read ↗

Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition.Semantic proximity Read ↗

Early growth conditions, phenotypic development and environmental change.Semantic proximity Read ↗

Fetal origins of developmental plasticity: are fetal cues reliable predictors of future nutritional environments?Semantic proximity Read ↗

Evidence for possible period 2 gene mediation of the effects of alcohol exposure during the postnatal period on genes associated with maintaining metabolic signaling in the mouse hypothalamus.Semantic proximity Read ↗

Early Postnatal Nutrition Determines Adult Pancreatic Glucose-Responsive Insulin Secretion and Islet Gene Expression in RatsSemantic proximity Read ↗

Mechanisms for the environmental regulation of gene expression: ecological aspects of animal development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.