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Article

Association between T102C and A-1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: relevance for treatment with antipsychotic drugs.

Clinical chemistry and laboratory medicine - 1 Jan 2007

Peñas-Lledó Eva M, Dorado Pedro, Cáceres Macarena C, de la Rubia Alfredo, Llerena Adrián

Abstract excerpt

BACKGROUND: An involvement of serotonin receptor 2A (5-HT2A) in the aetiology of schizophrenia has been hypothesised. The 5-HT2A receptor also appears to be an important site of action of atypical antipsychotic drugs. Indeed, association between schizophrenia and the T102C silent polymorphism of the 5-HTR2A gene has been reported. Another polymorphism in the promoter region of 5-HTR2A (A-1438G) in linkage...

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Identifiers

PMID: 17617023
DOI: 10.1515/CCLM.2007.181

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