Article
Differential gene expression of phosphoglyceric kinase (PGK) and hypoxic adaptation in chicken.
Science in China. Series C, Life sciences - 1 Jun 2007
Wang CunFang, Yuan CunZhong, Zhang Lao, Wu ChangXin, Li Ning
Abstract excerpt
Four single-nucleotide polymorphisms (SNP) of the Phosphoglyceric Kinase (PGK) gene were discovered based on comparison of the sequences from an altiplano chicken breed (Tibetan chicken) and two lowland breeds (White Leghorn and Shouguang chicken). Gel-shift results indicate that one of these SNPs, an A-->G mutation at position 59 in exon10, is able to bind hypoxia-induced factor-l (HIF-1), functioning as a...
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