Article
Elucidating the spectrum of alpha-thalassemia mutations in Iran.
Haematologica - 1 Jul 2007
Hadavi Valeh, Taromchi Amir Hossein, Malekpour Mahdi, Gholami Behjat, Law Hai-Yang, Almadani Navid, Afroozan Fariba, Sahebjam Farhad, Pajouh Parisa, Kariminejad Roxana, Kariminejad Mohammad Hassan, Azarkeivan Azita, Jafroodi Maryam, Tamaddoni Ahmad, Puehringer Helene, Oberkanins Christian, Najmabadi Hossein
Abstract excerpt
Alpha thalassemia (alpha-thal) is one of the most common hemoglobin (Hb) disorders in the world. Alpha-globin genes are located on chromosome 16. The majority of alpha-thal mutations are deletions but point mutations are found as well. Since the Iranian population is a mixture of different ethnic groups, frequency and distribution of alpha-globin mutations in various regions of the country need to be clarified....
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