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Article

SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome.

Circulation - 10 Jul 2007

Medeiros-Domingo Argelia, Kaku Toshihiko, Tester David J, Iturralde-Torres Pedro, Itty Ajit, Ye Bin, Valdivia Carmen, Ueda Kazuo, Canizales-Quinteros Samuel, Tusié-Luna Maria Teresa, Makielski Jonathan C, Ackerman Michael J

Abstract excerpt

BACKGROUND: Congenital long-QT syndrome (LQTS) is potentially lethal secondary to malignant ventricular arrhythmias and is caused predominantly by mutations in genes that encode cardiac ion channels. Nearly 25% of patients remain without a genetic diagnosis, and genes that encode cardiac channel regulatory proteins represent attractive candidates. Voltage-gated sodium channels have a pore-forming alpha-subunit...

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Identifiers

PMID: 17592081
DOI: 10.1161/CIRCULATIONAHA.106.659086
PMCID: PMC3332546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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