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Article

Synthesis and Catabolism of γ-Hydroxybutyrate in SH-SY5Y Human Neuroblastoma Cells

26 Jun 2007

Abstract excerpt

gamma-Hydroxybutyrate (GHB) is an endogenous metabolite synthesized in the brain. There is strong evidence to suggest that GHB has an important role as a neurotransmitter or neuromodulator. The human aldo-keto reductase AKR7A2 has been proposed previously to catalyze the NADPH-dependent reduction of succinic semialdehyde (SSA) to GHB in human brain. In this study we have used RNA interference to evaluate the role...

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PMID: 17591773
DOI: 10.1074/jbc.m702465200

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