Article
Early onset vitreous amyloidosis in familial amyloidotic polyneuropathy with a transthyretin Glu54Gly mutation is associated with elevated vitreous VEGF.
The British journal of ophthalmology - 1 Dec 2007
O'Hearn T M, Fawzi A, He S, Rao N A, Lim J I
Abstract excerpt
AIM: To report the early vitreous involvement in a rare familial amyloidotic polyneuropathy (FAP) mutation and associated vitreous vascular endothelial growth factor (VEGF) levels. DESIGN: Observational case series. METHODS: Review of clinical, pathological, photographic, and angiographic records of two FAP siblings with severe vitreous involvement. Laboratory ELISA analysis of vitreous samples for VEGF, and DNA...
Topics
- Adult
- Age of Onset
- Amyloid Neuropathies, Familial
- Asian People
- Eye Diseases, Hereditary
- Fluorescein Angiography
- Fundus Oculi
- Glutamic Acid
- Glycine
- Humans
- Male
- Mutation
- Prealbumin
- Vascular Endothelial Growth Factor A