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Article

Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2

23 May 2007

Abstract excerpt

Preventative medicine: The natural products guttiferone G and hyperforin (1) as well as the synthetic aristoforin (2) are inhibitors of human SIRT1 and SIRT2. Guttiferone G and 2 are less toxic but stronger inhibitors of cell proliferation than 1. These compounds may be valuable tools for epigenetics and for the elucidation of the biological role of sirtuins in processes such as cancer, ageing, neurodegenerative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17516596
DOI: 10.1002/anie.200605207

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