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Predicting Hepatocellular Carcinoma by Detection of Aberrant Promoter Methylation in Serum DNA

15 Apr 2007

Abstract excerpt

PURPOSE: Most hepatocellular carcinomas (HCC) are diagnosed at an advanced stage. Hypermethylation of CpG islands in promoter regions is now recognized as an important early event in carcinogenesis and detection of methylated DNA has been suggested as a potential biomarker for early detection of cancer. There are no studies on epigenetic changes in samples from HCC patients before diagnosis. We explored the...

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PMID: 17438096
DOI: 10.1158/1078-0432.ccr-06-1900

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