Article
Linkage study of voltage-gated potassium channels in familial mesial temporal lobe epilepsy.
Arquivos de neuro-psiquiatria - 1 Mar 2007
Maurer-Morelli Cláudia Vianna, Marchesini Rafael Breglio, Secolin Rodrigo, Santos Neide Ferreira, Kobayashi Eliane, Cendes Fernando, Lopes-Cendes Iscia
Abstract excerpt
Voltage-gated potassium channels (VGKCs) play a critical role in the regulation of neuronal excitability and have been implicated in some types of epilepsies. Recently, autoimmune limbic encephalitis (LE) was associated with antibodies against VGKC. In addition, patients with LE showed partial epilepsy and increased T2 signal abnormalities in limbic structures. We have reported familial mesial temporal lobe...
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