Article
Investigation of founder effects for the Thr377Met Myocilin mutation in glaucoma families from differing ethnic backgrounds.
Molecular vision - 28 Mar 2007
Hewitt Alex W, Samples John R, Allingham R Rand, Järvelä Irma, Kitsos George, Krishnadas Subbaiah R, Richards Julia E, Lichter Paul R, Petersen Michael B, Sundaresan Periasamy, Wiggs Janey L, Mackey David A, Wirtz Mary K
Abstract excerpt
PURPOSE: The aim of this study was to determine if there is a common founder for the Thr377Met myocilin mutation in primary open angle glaucoma (POAG) families with various ethnic backgrounds. METHODS: Genomic DNA of 24 POAG-affected individuals from nine pedigrees with the Thr377Met mutation and 104 unaffected family members was genotyped with six microsatellite markers and four single nucleotide polymorphisms....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.