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Article

Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1.

Antimicrobial agents and chemotherapy - 1 Jun 2007

Rodríguez-Martínez J M, Velasco C, García I, Cano M E, Martínez-Martínez L, Pascual A

Abstract excerpt

The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant prevention concentration compared to strains without this gene. In the presence of qnrA1, mutations in gyrA and parC genes were easily selected to produce high levels of quinolone resistance.

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Identifiers

PMID: 17404007
DOI: 10.1128/AAC.01444-06
PMCID: PMC1891403

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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