Article
MCT1 and CD147 gene polymorphisms in standardbred horses.
Equine veterinary journal. Supplement - 1 Aug 2006
Reeben M, Koho N M, Raekallio M, Hyyppä S, Pösö A R
Abstract excerpt
REASONS FOR PERFORMING STUDY: Transport of lactate across membranes is facilitated by proton-monocarboxylate transporters (MCT). The most widely distributed isoform is MCT1, which needs an ancillary protein CD147. Studies on erythrocytes have shown that high activity of MCT1 is inherited as the dominant allele and that activity is regulated through CD147. Mutations of human MCT1 have been described that appear to...
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