Article
CASC2a gene is down-regulated in endometrial cancer.
Anticancer research - 1 Jan 2000
Baldinu Paola, Cossu Antonio, Manca Antonella, Satta Maria P, Sini Maria C, Palomba Grazia, Dessole Salvatore, Cherchi Pierluigi, Mara Laura, Tanda Francesco, Palmieri Giuseppe
Abstract excerpt
BACKGROUND: Chromosome 10q25-q26 has been strongly correlated to endometrial tumorigenesis. A novel human gene, CASC2, has previously been identified at chromosome 10q26. One out of the three alternative transcripted forms, CASC2a, has been demonstrated to be mutated at a low frequency in endometrial cancer (EC). In this study, the role of the CASC2a gene in cancer has been further defined. MATERIALS AND METHODS:...
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