Article
Clinical and molecular survey in 124 Chinese patients with Leigh or Leigh-like syndrome.
Journal of inherited metabolic disease - 1 Apr 2007
Zhang Y, Yang Y L, Sun F, Cai X, Qian N, Yuan Y, Wang Z X, Qi Y, Xiao J X, Wang X Y, Zhang Y H, Jiang Y W, Qin J, Wu X R
Abstract excerpt
Leigh syndrome is the most common mitochondrial disorder in children characterized by necrotic lesions in the central nervous system. Both mitochondrial DNA (mtDNA) and nuclear DNA defects in the mitochondrial respiratory chain can lead to this disease. To characterize the clinical and genetic traits of Leigh or Leigh-like syndrome patients in China, 124 unrelated cases were collected between 1992 and 2005....
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