Article
Hemoglobin variants and activity of the (K+Cl-) cotransport system in human erythrocytes.
Blood - 1 Feb 1992
Olivieri O, Vitoux D, Galacteros F, Bachir D, Blouquit Y, Beuzard Y, Brugnara C
Abstract excerpt
To determine if the activation of the (K+Cl-) cotransport system observed in hemoglobin (Hb) S- or C-containing erythrocytes is related either to a global change of isoelectric point of the Hb molecule or to the specific location of these mutations on the position 6 of the beta chain of Hb, we studied the (K+Cl-) cotransport system in erythrocytes containing beta chain variants exhibiting either the Glu----Lys...
Topics
- Biological Transport
- Chlorides
- Erythrocytes
- Globins
- Humans
- In Vitro Techniques
- Isoelectric Point
- Mutation
- Potassium
- Structure-Activity Relationship