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Article

Impaired protein stability of 11beta-hydroxysteroid dehydrogenase type 2: a novel mechanism of apparent mineralocorticoid excess.

Journal of the American Society of Nephrology : JASN - 1 Apr 2007

Atanasov Atanas G, Ignatova Irena D, Nashev Lyubomir G, Dick Bernhard, Ferrari Paolo, Frey Felix J, Odermatt Alex

Abstract excerpt

Apparent mineralocorticoid excess (AME) is a severe form of hypertension that is caused by impaired activity of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which converts biologically active cortisol into inactive cortisone. Mutations in HSD11B2 result in cortisol-induced activation of mineralocorticoid receptors and cause hypertension with hypokalemia, metabolic alkalosis, and suppressed...

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Identifiers

PMID: 17314322
DOI: 10.1681/ASN.2006111235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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