Article
A randomized trial to evaluate continuation versus discontinuation of lamivudine in individuals failing a lamivudine-containing regimen: the COLATE trial.
Antiviral therapy - 1 Jan 2006
Fox Zoe, Dragsted Ulrik B, Gerstoft Jan, Phillips Andrew N, Kjaer Jesper, Mathiesen Lars, Youle Mike, Katlama Christine, Hill Andrew, Bruun Johan N, Clumeck Nathan, Dellamonica Pierre, Lundgren Jens D
Abstract excerpt
BACKGROUND: Lamivudine (3TC) therapy can cause the emergence of M1841/V. Previous studies suggest a higher fidelity of the mutant reverse transcriptase and lower replication capacity of the mutant virus. No data exist from clinical comparative studies evaluating the benefit of M1841/V in patients receiving combination antiretroviral therapy (cART). METHODS: HIV-1-infected adults failing a 3TC-containing regimen...
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