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Role of Physical Activity in Modulating Breast Cancer Risk as Defined byAPCandRASSF1APromoter Hypermethylation in Nonmalignant Breast Tissue

1 Feb 2007

Abstract excerpt

Physical activity reduces breast cancer risk. Promoter hypermethylation of the tumor suppressor genes APC and RASSF1A, which is potentially reversible, is associated with breast cancer risk. We conducted a cross-sectional study in 45 women without breast cancer to determine the association of physical activity with promoter hypermethylation of APC and RASSF1A in breast tissue. We used quantitative...

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PMID: 17301249
DOI: 10.1158/1055-9965.epi-06-0700

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