Article
In vivo turnover study demonstrates diminished clearance of lipoprotein(a) in hemodialysis patients.
Kidney international - 1 May 2007
Frischmann M E, Kronenberg F, Trenkwalder E, Schaefer J R, Schweer H, Dieplinger B, Koenig P, Ikewaki K, Dieplinger H
Abstract excerpt
Lipoprotein(a) (Lp(a)) consists of a low-density lipoprotein-like particle and a covalently linked highly glycosylated protein, called apolipoprotein(a) (apo(a)). Lp(a) derives from the liver but its catabolism is still poorly understood. Plasma concentrations of this highly atherogenic lipoprotein are elevated in hemodialysis (HD) patients, suggesting the kidney to be involved in Lp(a) catabolism. We therefore...
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