Evaluation of the risk for Tay-Sachs disease in individuals of French Canadian ancestry living in new England.

doi:10.1373/clinchem.2006.082727

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Article

Evaluation of the risk for Tay-Sachs disease in individuals of French Canadian ancestry living in new England.

Clinical chemistry - 1 Mar 2007

Martin Dianna C, Mark Brian L, Triggs-Raine Barbara L, Natowicz Marvin R

Abstract excerpt

BACKGROUND: The assessment of risk for Tay-Sachs disease (TSD) in individuals of French Canadian background living in New England is an important health issue. In preliminary studies of the enzyme-defined carrier frequency for TSD among Franco-Americans in New England, we found frequencies (1:53) higher than predicted from the incidence of infantile TSD in this region. We have now further evaluated the risk for...

Topics

Adult
Canada
Genetic Predisposition to Disease
Heterozygote
Humans
Massachusetts
Mutation
Risk
Tay-Sachs Disease
White People
beta-Hexosaminidase alpha Chain
beta-N-Acetylhexosaminidases

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Open in PubMed

Identifiers

PMID: 17259242
DOI: 10.1373/clinchem.2006.082727

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