Article
Investigation of the VDR gene polymorphisms association with susceptibility to colorectal cancer.
Cell biochemistry and function - 1 Jan 2000
Yaylim-Eraltan Ilhan, Arzu Ergen H, Arikan Soykan, Okay Erdem, Oztürk Oğuz, Bayrak Savaş, Isbir Turgay
Abstract excerpt
The effects of 1,25-dihydroxyvitamin D3 are mediated by binding to a specific intracellular vitamin D receptor (VDR), which has been identified in a variety of tissues. Certain polymorphisms in the VDR gene have been associated with various neoplasms. For this purpose, we studied whether VDR TaqI or FokI genotype are associated with serum 25-hydroxyvitamin D3 in 52 controls and 26 patients with colorectal cancer....
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