Article
The G51S purine nucleoside phosphorylase polymorphism is associated with cognitive decline in Alzheimer's disease patients.
Human psychopharmacology - 1 Mar 2007
Tumini Emanuela, Porcellini Elisa, Chiappelli Martina, Conti Chiara M, Beraudi Alina, Poli Alessandro, Caciagli Francesco, Doyle Robert, Conti Pio, Licastro Federico
Abstract excerpt
Alzheimer's disease (AD) is a polygenic and multifactorial complex disease, whose etiopathology is still unclear, however several genetic factors have shown to increase the risk of developing the disease. Purine nucleotides and nucleosides play an important role in the brain. Besides their role in neurotransmission and neuromodulation, they are involved in trophic factor release, apoptosis, and inflammatory...
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