Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of NPHS2 and WT1 in frequently relapsing and steroid-dependent nephrotic syndrome.

Pediatric nephrology (Berlin, Germany) - 1 Apr 2007

Gbadegesin Rasheed, Hinkes Bernward, Vlangos Christopher, Mucha Bettina, Liu Jinhong, Hopcian Jeff, Hildebrandt Friedhelm

Abstract excerpt

Idiopathic nephrotic syndrome is a common pediatric kidney disease, 80% of all cases are steroid sensitive (SSNS). A significant proportion of children with SSNS will have a frequently relapsing or steroid-dependent course (FRNS/SDNS) that is associated with significant treatment-related morbidity. Mutations in NPHS2 account for more than 28% of all cases of steroid-resistant nephrotic syndrome (SRNS) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Heterozygote
Share to Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Membrane Proteins

Share to Nephrotic Syndrome

Share to Recurrence

Share to Steroids

Share to WT1 Proteins

Source

Identifiers

PMID: 17216259
DOI: 10.1007/s00467-006-0377-y

Genes

NPHS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of NPHS2 and WT1 in frequently relapsing and steroid-dependent nephrotic syndrome.PMID 17216259Read ↗

Genetic screening in children with challenging nephrotic syndrome.Semantic proximity Read ↗

Steroid-resistant nephrotic syndrome: impact of genetic testing.Semantic proximity Read ↗

NPHS2 gene in steroid-resistant nephrotic syndrome: prevalence, clinical course, and mutational spectrum in South-West Iranian children.Semantic proximity Read ↗

Novel mutations in NPHS2 detected in both familial and sporadic steroid-resistant nephrotic syndrome.Semantic proximity Read ↗

Clinical utility of genetic testing in children and adults with steroid-resistant nephrotic syndrome.Semantic proximity Read ↗

Retrospective mutational analysis of NPHS1, NPHS2, WT1 and LAMB2 in children with steroid-resistant focal segmental glomerulosclerosis - a single-centre experience.Semantic proximity Read ↗

Spectrum of steroid-resistant and congenital nephrotic syndrome in children: the PodoNet registry cohort.Semantic proximity Read ↗

Identification of monogenic variants in steroid-resistant and steroid-sensitive nephrotic syndrome.Semantic proximity Read ↗

NPHS Mutations in Pediatric Patients with Congenital and Steroid-Resistant Nephrotic Syndrome.Semantic proximity Read ↗

Molecular genetic analysis of Steroid Resistant Nephrotic Syndrome: Detection of a novel mutationSemantic proximity Read ↗

NPHS2 mutations in steroid-resistant nephrotic syndrome: a mutation update and the associated phenotypic spectrum.Semantic proximity Read ↗

Analysis of 24 genes reveals a monogenic cause in 11.1% of cases with steroid-resistant nephrotic syndrome at a single center.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.